OHIO — Ohio Republican Josh Mandel, the former state treasurer and former Marine, announced Wednesday he's making a third run for the U.S. Senate.

“I’m going to Washington to fight for President Trump’s America First Agenda and to pulverize the Uniparty – that cabal of Democrats and Republicans who sound the same, stand for nothing and are more interested in cocktail party invites than defending the Constitution," Mandel wrote in a press release.

Mandel, 43, said the second impeachment of former President Donald Trump makes his "blood boil" and has motivated him to run again. He believes the charges against Trump are unfounded. Mandel was the first Ohio Republican to voice his support for Trump in 2016. 

Former Ohio State Treasurer @JoshMandelOhio sends out this email announcing his third run for U.S. Senate.

He becomes the first Ohio Republican to officially declare in the 2022 race and says he was motivated by the “sham and unconstitutional impeachment.” pic.twitter.com/lCFK3NhL4v

— Taylor Popielarz (@TaylorPopielarz) February 10, 2021

"It’s sickening to see radical liberals and fake Republicans in Washington engage in this second assault on President Donald Trump and the millions of us who supported him," Mandel said.

His announcement comes about two weeks after Sen. Rob Portman announced he won't be re-running again. It's possible Mandel could go up against former Ohio Republican Party Chair Jane Timken, who resigned last week. She didn't say whether she'd run for the Senate, but that she would announce her plans soon. 

On the Democratic side, U.S. Rep Tim Ryan and former Ohio Department of Health Director Amy Acton have shown interest in running for the position. 

"Many Ohioans have shared with me their concerns and the daily challenges they face. They have expressed a need for a new approach that can help them, and their communities thrive. I am humbled by the outpouring of interest and support. For that reason, I am stepping down from my role at The Columbus Foundation in order to carefully consider how I can best be of service at this crucial time. Whatever my decision, I know with absolute certainty I won’t stop working to provide healing and hope to all Ohioans," Acton wrote. 

Mandel won two terms as state treasurer. His second run for Senate in 2018 came to halt after he dropped his campaign citing health issues. He also ran in 2012, but was defeated by Sen. Sherrod Brown, who also won in 2018. 

The Associated Press contributed to this report.