The NFL is reducing isolation time for players who test positive for COVID-19 and are asymptomatic, including unvaccinated players, to five days from 10.

The league and the NFL Players Association revised the protocols after the CDC changed its guidelines for those who are asymptomatic, recommending a five-day isolation period and masking over the second five days.

The changes could allow Colts quarterback Carson Wentz to return for Sunday's key game against Las Vegas after Indianapolis placed him on the reserve/COVID-19 list.

It was not immediately clear whether Wentz tested positive for the virus or was deemed a close contact to someone else who had tested positive. However, if Wentz has no symptoms, he could be cleared to play.

The Tennessee Titans, who can clinch the AFC South with either a win or a Colts' loss, added two more in linebacker Jayon Brown and practice squad receiver Cody Hollister, who has played three of the past four games including one start. That brings the Titans' total to nine, not counting a 10th player out for the season on injured reserve.

The timing couldn't be worse for the Colts, who have rebounded from a 1-4 start to win eight of their past 10. They can clinch one of the seven AFC playoff spots with a win over the Raiders.

Indy's move comes one day after five players including right tackle Braden Smith were added to a rapidly expanding COVID-19 list and less than 24 hours after coach Frank Reich was asked whether any additional precautions would be taken to protect Wentz.

“Yes, there has been with the team, as far as — really for every player," Reich said. “So, we’ll have a plan for the whole team, a plan for certain individuals, Carson being one of them but not the only person. I don’t want to go into detail on every person we might do something a little extra with, but those things are being talked about."

Wentz's backup is rookie Sam Ehlinger, who has played in three games but has not thrown a pass this season. He was a sixth-round draft pick.

Veteran Brett Hundley and James Morgan are on Indy's practice squad. Hundley has gone 3-6 as a starter during his NFL career.

Indy won Saturday at Arizona despite missing six starters because of COVID-19 and losing two more in the first half. The absences forced Indy to play with only one of its five regular offensive line starters, Smith.

It's unclear how many, if any, of those players may return Sunday.

But Reich made one thing clear Monday — the Colts did not ask last season's starter, Philip Rivers, about coming out of retirement to help.

“No," Reich said. “Right now we’re just in the situation that we’re in. We’re happy with the guys that we’ve got here."

Tampa Bay Buccaneers coach Bruce Arians has tested positive for COVID-19 and is currently isolating at home.

The team said Tuesday that assistant head coach/run game coordinator Harold Goodwin will serve as interim head coach in Arians’ absence. The reigning Super Bowl champions visit the New York Jets on Sunday.

Arians said in a statement released by the team: “I tested positive for COVID-19 this morning but have only experienced mild symptoms to this point. Harold Goodwin will take over my duties during my absence. I have complete confidence in him and the rest of our coaching staff to prepare the team for this week’s game against the Jets. I look forward to rejoining the team and being back in the facility as soon as I can test back in.”

Meanwhile, the Bucs also placed cornerbacks Jamel Dean and Sean Murphy-Bunting on the reserve/COVID-19 list. That increases the number of Tampa Bay players on the list to five.

Also:

— Patriots rookie quarterback Mac Jones could be without his top backup against the Jaguars after veteran Brian Hoyer was added to the reserve/COVID-19 list, along with linebackers Josh Uche and Brandon King.

Hoyer, who is on his fourth stint in New England, has previously served in backup roles to Tom Brady and Cam Newton. He has been Jones’ backup for each of the first 15 games this season.

If Hoyer is unavailable, 2019 fourth-round pick Jarrett Stidham could move into that role. The promotion would come a little more than a month after Stidham was added back onto the active roster after starting the season on injured reserve with a back injury. He has appeared in eight career games.

Hoyer, Uche and King make it five Patriots players who have been added to the COVID-19 list in two days. Linebackers Matt Judon and Ja’Whaun Bentley, two of the Patriots most productive defensive players, were added Monday. While New England has some depth at linebacker, Judon has been its best pass rusher and leads the team with 12 1/2 sacks.

Linebackers coach Jerod Mayo said Tuesday that the team is prepared to adjust as necessary on defense.

“We still have guys in our room that played a lot of ball, and I would also say, you either can replace people with another person or you can replace it through scheme,” Mayo said. “So we’re still going through that process right now. Who do we want to put out on the field, what the game plan is for this week, but at the end of the day, the guys that are out there, they’ll be ready to go. Hopefully we get those guys back, but just like I said earlier, we’ve just got to treat it as an injury.”

— The Green Bay Packers have placed tight end Marcedes Lewis and linebacker Oren Burks on the reserve/COVID-19 list. That comes one day after the Packers placed guard Ben Braden, linebacker Tipa Galeai, wide receiver/punt returner Amari Rodgers and linebacker Ty Summers on the reserve/COVID-19 list and put defensive lineman R.J. McIntosh on the practice squad reserve/COVID-19 list.

— The Jacksonville Jaguars placed three more players on the reserve/COVID-19 list: tight end Jacob Hollister, defensive tackle Jay Tufele and linebacker Damien Wilson. That brings the team's total to 19 players on the list, including eight defensive linemen and four tight ends.

— The Cincinnati Bengals placed wide receiver Auden Tate on the reserve/COVID-19 list. Tate hasn't played since Week 7 and is on injured reserve because of a calf injury.

— The Philadelphia Eagles placed wide receiver John Hightower on the practice squad reserve/COVID-19 list.