LOS ANGELES (CNS) -— The COVID-19 pandemic could result in net losses from $3.2 trillion up to $4.8 trillion in gross domestic product over the course of two years, according to a USC study released Monday.

USC economists project that a best-case scenario for the United States hinges on whether initial mandatory closures and social distancing measures were sufficient to control the rise in coronavirus cases. In a worst-case scenario, infections would ramp up considerably after businesses reopen, forcing another round of closures.

The study comes just as new restrictions -- the strongest in months -- go into effect in Los Angeles County and elsewhere as officials battle an unprecedented surge in coronavirus cases.

The pandemic's economic impact depends on factors such as the duration and extent of the business closures, the gradual reopening process, infection rates and fatalities, avoiding public places, and pent-up consumer demand, according to researchers with the USC Center for Risk and Economic Analysis of Terrorism Events.

Real GDP is a measure, adjusted for inflation, that reflects the value and the quantity of final goods and services produced by a nation's economy in a given year.

"In a best-case scenario, we would see containment measures, such as masks and social distancing become more widespread, and possibly even a vaccine by next year, and then businesses and institutions would be able to reopen at an accelerated pace," said study team leader Adam Rose, who is the director of USC CREATE and a research professor at the USC Price School of Public Policy.

"But in a worst-case scenario, these countermeasures wouldn't materialize, and reopenings would happen slowly, particularly because we would continue to see waves of infection," he said. "Then, more people would likely lose their jobs, and the impacts of this disaster would continue to mount."

The researchers found that the mandatory closures and partial reopenings alone could result in a 22% loss of U.S. GDP in just one year and an even greater loss of GDP over two years. Other key factors, though, will influence how disastrous the losses may be, they noted in the study published Monday in the journal Economics of Disasters and Climate Change.

The research team noted that China has not sustained such losses due to aggressive containment measures resulting in a shorter lockdown period. They project that in a worst-case scenario, the U.S. GDP loss due to COVID will be more than quadruple that of China.

In early March, several states responded to a rise in COVID-19 cases by ordering the closures of non-essential businesses such as restaurants, bars, salons and retail stores. Some also halted or reduced public services to limit the spread, but many others took little or no action.

Researchers at CREATE who are experts on modeling economic consequences of disasters analyzed the potential economic impact in three scenarios ranging from moderate to disastrous.

Using a computerized economic model, the researchers accounted for these other factors in the three scenarios. They varied the decline in the workforce due to workers becoming sick with or dying of the virus, workers adopting new behaviors like staying home to avoid infection, increased demand for COVID health care, potential resilience through telework, increased demand for communication services, and increased pent-up consumer demand.

The researchers conducted a synthesis of the literature of projections on the severity and possible duration of the pandemic.

For the scenarios, which span from March 2020 through February 2022, the compilation of findings indicated that the number of COVID-related deaths in the United States could range from more than 300,000 to, in a worst-case scenario, 1.75 million.

Anywhere from 365,000 to as many as 2.5 million COVID patients could end up in an intensive care unit, while another 860,000 to nearly 6 million patients may be hospitalized but not treated in an ICU. The projected number of people who will be treated for COVID as outpatients may vary from about 2.6 million to 18 million.

Among other highlights of the study, the researchers projected:

• 54 million to 367 million work days would be lost due to people getting sick or die from COVID
• 2 million to nearly 15 million work days would be lost due to employees staying home to care for sick loved ones
• job losses could range from 14.7% to 23.8%, and in the worst case affect an estimated 36.5 million workers
• demand for health care has risen with COVID infections. Medical expenses due to COVID-19 from March 2020 to February 2022 could range from nearly $32 billion to $216 billion
• a loss in demand for some services -- such as the use of public transit and school attendance, restaurant dining and travel -- as people avoid public places and services to reduce their risk of exposure
• an uptick in demand for communication services, as many employees during this pandemic have had to work from home
• an increase in pent-up demand since consumers are unable to spend money on big-ticket items such as cars, as well as travel, restaurants, hotels, merchandise, fitness, sporting events and concerts during the closures, and, to a lesser extent, during the phased reopenings.

While the researchers have found that the mandatory closures and re- openings are the most influential factor in the economy's decline, consumer avoidance behavior also has a significant effect.

For the study, the researchers assumed that various people avoided work, did not attend in-person classes at schools, and stopped going to restaurants, activities and social gatherings to reduce their risk of infection.

"Because people have had to avoid activities, this has had a significant impact on economic losses," said Dan Wei, a CREATE research fellow and research associate professor at the USC Price School for Public Policy. "Based on our model, we estimate that avoidance behavior can result in nearly $900 billion losses in U.S. GDP in the worst-case scenario. Because consumers in places like California can't engage in many activities like eating inside a restaurant, they are saving their money."

The economic losses from closures and avoidance behavior could be partly offset by increased consumer spending after reopening, the researchers said.

"The key question is: When will we see a complete reopening across this country? We simply cannot predict that, especially in light of the fact that we have not gained control of the spread of the disease," Rose said.